Author/Authors :
Movagharnejad، Kourosh Kourosh نويسنده Department of Pathology, Rohani Hospital, Babol University of Medical Sciences, Babol, Iran Movagharnejad, Kourosh Kourosh , Sharbatdaran ، Majid نويسنده Department of Pathology, Babol University of Medical Sciences, Babol, Iran. , , Sheffaee، Shahryar Shahryar نويسنده Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran Sheffaee, Shahryar Shahryar , Kashifard ، Mehrdad نويسنده Department of Internal Medicine, Babol University of Medical Sciences, Babol, Iran , , Sedaghat، Sadegh Sadegh نويسنده Ayatollah Roohani Hospital, Babol University of Medical Sciences, Babol, Iran. Sedaghat, Sadegh Sadegh
Abstract :
Gastric adenocarcinoma is the second leading cause of death due to cancer in the world and in advanced stages the prognosis is poor even with current therapies. Over-expression of HER-2/neu has been seen in several cancers such as gastric cancer and its expression is associated with poor prognosis. The aim of this study is to evaluate the over-expression of HER-2/neu in gastric biopsy samples of patients with gastric carcinoma diagnosis; and to evaluate its probable relationship with clinical and pathological findings. The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011. The over-expression of HER-2/neu has been observed in 6 patients (10%) and this over-expression was greater in the intestinal type of gastric adenocarcinoma than the diffuse type (12% vs. 6%); however, no statistically significant correlation between HER-2/neu expression and subtype, degree of differentiation, tumor type and age was observed. This over-expression was greater in differentiated types than undifferentiated types (18% vs. 5%).
