Psychosocial correlates of 6-n-propylthiouracil (PROP) ratings in a birth cohort

This study investigated the relation between ratings of 6-n-propylthiouracil (PROP) and two psychosocial constructs, socioeconomic status and IQ, which are related to health outcomes. A 3.2 mM solution of PROP was rated by 922 32-year-old members of a birth cohort (450 women) relative to the strongest imaginable sensation of any kind using the generalised Labelled Magnitude Scale. Women had higher PROP ratings than men. Following normalisation of PROP ratings, multiple linear regression showed that higher ratings were independently associated with lower childhood socioeconomic status, lower childhood IQ scores and ratings of an imagined stimulus made on the same scale (r2=0.12). Results suggest that psychosocial variables, sex and scale use, in addition to established genetic determinants, may help explain variability in ratings of supra-threshold concentrations of PROP.