Title of article
Synthesis of 3-β-d-ribofuranosyl-1 H-pyrazole-4-carboxamide
Author/Authors
Yasufumi Nishiyama، نويسنده , , Natsu Nishimura، نويسنده , , Naoko Kuroyanagi، نويسنده , , Isamu Maeba، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 1997
Pages
6
From page
283
To page
288
Abstract
The synthesis of 3-β-d-ribofuranosyl-1 H-pyrazole-4-carboxamide (11) is described. Treatment of enaminone glycoside 1 with trimethyl orthoformate afforded the aldehyde 2. The aldehyde 2 was oximated with hydroxylamine. Oxime 3 was cyclized with hydrazine to afford the pyrazole 8. The pyrazole 8 was dehydrated with acetic anhydride, and the nitrile 9 was treated with nickel acetate in acetic acid. The resulting carboxamide 10 was deblocked by aq ammonia gave 11.
Keywords
Synthesis , C-Nucleoside , Pyrazole-4-carboxamide , Glycosyl enaminone
Journal title
Carbohydrate Research
Serial Year
1997
Journal title
Carbohydrate Research
Record number
961783
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