Title of article
Synthesis and biological evaluation of ureido and thioureido derivatives of 2-amino-2-deoxy-d-glucose and related aminoalcohols as N-acetyl-β-d-hexosaminidase inhibitors
Author/Authors
Cécile Tournaire-Arellano، نويسنده , , Salomé Younes-El Hage، نويسنده , , Patricia Valès، نويسنده , , Raymond Caujolle، نويسنده , , Albertine Sanon، نويسنده , , Christian Bories، نويسنده , , Philippe M. Loiseau، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 1998
Pages
17
From page
47
To page
63
Abstract
Ureido and thioureido derivatives of 2-acetamido-2-deoxy-β-d-glucose, 1-amino-1-deoxy-d-glucitol and 2-(2-aminoethoxy)ethanol were prepared as N-acetyl-β-d-hexosaminidase (NAHase) inhibitors and were evaluated on Trichomonas vaginalis NAHase. Although none showed complete inhibition of the enzyme at 100 μM, 1-amino-1-deoxy-d-glucitol derivatives acted as competitive inhibitors of the NAHase of T. vaginalis.
Keywords
Trichomonas vaginalis , Hexosaminidase inhibitors , 3 , 6-Tetra-O-acetyl-2-amino-2-deoxy-?-d-glucose , 1-Amino-1-deoxy-d-glucitol , 2-(2-Aminoethoxy)ethanol , Ureido and thioureido derivatives , 4 , 1
Journal title
Carbohydrate Research
Serial Year
1998
Journal title
Carbohydrate Research
Record number
962229
Link To Document