Synthesis of site-specific, deuterium-substituted α-l-Rhap-(1→2)-α-l-Rhap-Ome

The disaccharide α-l-Rhap-(1→2)-α-l-(2-2H)Rhap-OMe has been synthesized. The site-specific deuteration was performed at C-2 by reduction of a suitably protected β-linked 2-ulose derivative. In addition, α-l-Rhap-(1→2)-α-l-(2-2H)Rhap-O(2H3)Me was also synthesized.