Synthesis of kanamycin A analogs containing a 6-amino-6-deoxyglycofuranose moiety Original Research Article

Three kanamycin A analogs containing 6-amino-6-deoxyglycofuranoses have been prepared as candidates for potential activity against resistant bacteria producing 6′-N-acetyltransferase. They are 4-O-(6-amino-3,5,6-trideoxy-α-d-, -β-d-, and -β-l-erythro-hexofuranosyl)-6-O-(3-amino-3-deoxy-α-d-glucopyranosyl)-2,5-dideoxy-5-epi-5-fluorostreptamine. Structure–activity relationships of these compounds are discussed.