Chemical synthesis of sulfated oligosaccharides with a β-d-Gal-(1→3)-[β-d-Gal-(1→4)-(α-l-Fuc-(1→3)-β-d-GlcNAc-(1→6)]-α-d-GalNAc sequence Original Research Article

The syntheses of two sulfated pentasaccharides: β-d-Gal6SO3Na-(1→3)-[β-d-Gal-(1→4)-α-l-Fuc-(1→3)-β-d-GlcNAc-(1→6)]-α-d-GalNAc→OMe (1) and β-d-Gal6SO3Na-(1→3)-[β-d-Gal-(1→4)-α-l-Fuc-(1→3)-β-d-GlcNAc6SO3Na-(1→6)]-α-d-GalNAc→OMe (2) by using LewisX trisaccharides 12 and 16 as glycosyl donors are described. Sulfated oligosaccharides 1–2 and intermediate compounds are fully characterized by 2D 1H–1H DQF-COSY and 2D ROESY experiments.