Title of article
A very efficient method to cleave Lipid A and saccharide components in bacterial lipopolysaccharides
Author/Authors
E Manzo، نويسنده , , A Molinaro، نويسنده , , E Bedini، نويسنده , , C De Castro، نويسنده , , M Parrilli، نويسنده ,
Issue Information
هفته نامه با شماره پیاپی سال 2001
Pages
4
From page
339
To page
342
Abstract
A novel mild procedure for the selective cleavage of ketosidic linkages is developed using ceric ammonium nitrate (CAN) in anhydrous N,N-dimethylformamide. Its application to lipopolysaccharides (LPS) is very significant because in the so far investigated LPS, the connection between the Lipid A region and the oligo(poly)saccharide part is always a keto-sugar. This procedure has been tested on LPS of Escherichia coli which contains Kdo as a linker between Lipid A and OPS and on Acinetobacter haemoliticus which contains d-glycero-d-talo-2-octulopyranosonic acid (Ko) as a linker and it performed efficiently in both cases.
Keywords
Ketosidic cleavage , d-glycero-d-talo-2-Octulopyranosonic acid , Kdo , Gram-negative bacteria , O-antigen , Endotoxin , Ceric ammonium nitrate
Journal title
Carbohydrate Research
Serial Year
2001
Journal title
Carbohydrate Research
Record number
963263
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