Microwave-assisted glycosylation for the synthesis of glycopeptides

An efficient one-step synthesis of O-linked glycosylamino acids is described. This methodology converts commercially available peracetylated mono- and disaccharides activated by cheap and environmentally safe FeCl3 under microwave irradiation with Fmoc-Ser-OBn to the corresponding β-glycosides in short reaction times and moderate yields.