Syntheses of chlorogenin 6α-O-acyl-3-O-β-chacotriosides and their antitumor activities Original Research Article

Chlorogenin 3-O-β-chacotrioside (1) and its 6α-O-acyl derivatives (2–6) were concisely synthesized. Introduction of a hydroxyl or acyloxy group onto the C-6 of the steroidal aglycone of dioscin decreased significantly the cytotoxicity of the parent saponin (dioscin).