Author/Authors :
Shusheng Wang، نويسنده , , Dan Liu، نويسنده , , Xu Zhang، نويسنده , , Shengyu Li، نويسنده , , Yongxu Sun، نويسنده , , Jia Li، نويسنده , , Yifa Zhou، نويسنده , , Liping Zhang، نويسنده ,
Abstract :
Eight novel toxoflavin glycosides, which are potential prodrugs in antibody directed enzyme prodrug therapy (ADEPT), were synthesized. The structures of all toxoflavin glycosides were characterized by 13C NMR spectroscopy, elemental analysis, and MS. Their enzymatic hydrolysis activities were tested against β-glucosidase (EC.3.2.1.21).
Keywords :
Toxoflavins , Toxoflavin glycosides , Prodrugs , ?-Glucosidase , Anticancer
