Title of article
A comparative study of different glycosylation methods for the synthesis of d-mannopyranosides of Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-l-proline allyl ester
Author/Authors
Dong-Jun Lee MA، نويسنده , , Renata Kowalczyk، نويسنده , , Victoria J. Muir، نويسنده , , Phillip M. Rendle، نويسنده , , Margaret A. Brimble، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2007
Pages
7
From page
2628
To page
2634
Abstract
The synthesis of Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-4-O-[(2,3,4,6-tetra-O-acetyl)-α-d-mannopyranosyl]-l-proline allyl ester and Nα-fluorenylmethoxycarbonyl-trans-4-hydroxy-4-O-[(2,3,4,6-tetra-O-benzoyl)-α-d-mannopyranosyl]-l-proline allyl ester is described. Glycosylation using Königs–Knorr conditions with a benzoyl protected glycosyl donor provided the optimum method. Removal of the allyl ester gave two mannosylated building blocks suitable for solid phase glycopeptide synthesis.
Keywords
Sugar amino acids , O-Glycosylation , trans-4-Hydroxy-proline , Vaccines and C-lectins , Mannose
Journal title
Carbohydrate Research
Serial Year
2007
Journal title
Carbohydrate Research
Record number
965323
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