Title of article
Synthesis of 6-O-methotrexylhyaluronan as a drug delivery system Original Research Article
Author/Authors
Claudia Sorbi، نويسنده , , Massimo Bergamin، نويسنده , , Susanna Bosi، نويسنده , , Francesca Dinon، نويسنده , , Vincent Aroulmoji، نويسنده , , Riaz Khan، نويسنده , , Erminio Murano، نويسنده , , Stefano Norbedo، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2009
Pages
7
From page
91
To page
97
Abstract
Selective halogenation of hyaluronan and partial halogen substitution by methotrexate led to 6-chloro-6-deoxy-6-O-methotrexylhyaluronan, a potential antitumor drug. The remaining halogen could be further substituted by a second organic carboxylate, leading to mixed esters. 6-O-Acetyl-6-O-methotrexylhyaluronan and 6-O-butyryl-6-O-methotrexylhyaluronan were thus synthesized and characterized by NMR spectroscopy.
Keywords
Hyaluronan conjugate , Methotrexate , Drug delivery system
Journal title
Carbohydrate Research
Serial Year
2009
Journal title
Carbohydrate Research
Record number
965680
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