Title of article
Synthesis, characterization, and cytotoxicity of some novel glycosyl thiazol-2-imines as antitumoral agents
Author/Authors
Qing Zhao، نويسنده , , Zhi-Chao Shen ، نويسنده , , Hui Zheng، نويسنده , , Jinchao Zhang، نويسنده , , Pengfei Zhang، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2010
Pages
5
From page
437
To page
441
Abstract
A series of novel glycosyl thiazol-2-imines (3a–g) have been synthesized regioselectively in good yields from the hydrolysis of thiazol-2(3H)-imine-linked glycoconjugates. The glycosyl thiazol-2-imines were evaluated for their antitumor activity against Hela (cervical carcinoma), HCT-8 (colon carcinoma) and Bel-7402 (liver carcinoma). Among the compounds screened, 1-benzoyl-4-(4-nitrophenyl)-3-β-d-glucopyranosyl-thiazol-2(3H)-imine (3c) was found to be the most active compound against HCT-8.
Keywords
Thiazol-2-imines , Antitumoral agents , Cytotoxic activities , Glycoconjugates
Journal title
Carbohydrate Research
Serial Year
2010
Journal title
Carbohydrate Research
Record number
966697
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