Author/Authors :
Haruhito Kato، نويسنده , , Hirotaka Uzawa، نويسنده , , Takehiro Nagatsuka، نويسنده , , Satoshi Kondo، نويسنده , , Keita Sato، نويسنده , , Isaac Ohsawa، نويسنده , , Mieko Kanamori-Kataoka، نويسنده , , Yoshiyuki Takei، نويسنده , , Shigenori Ota، نويسنده , , Masahiro Furuno، نويسنده , , Hirofumi Dohi، نويسنده , , Yoshihiro Nishida، نويسنده , , Yasuo Seto، نويسنده ,
Abstract :
A series of sugar-modified porous silica monoliths with different sugar ligands (β-lactoside, β-N-acetyllactosaminide, β-d-galactoside, β-d-N-acetylgalactosaminide and β-d-glucoside) and linkers were prepared and evaluated using plant toxins and lectins including ricin and a Ricinus communis agglutinin (RCA120). Among these sugar monoliths, a lactose monolith carrying a triethylene glycol spacer adsorbed ricin and RCA120 with the highest efficiency. The monolith showed no binding with albumin, globulin, and lectins from Jack beans, Osage orange, Amur maackia and wheat germ. All these data support the utility of the lactose-modified monolith as a tool for adsorption and decontamination of plant toxins.
Keywords :
Lactoside , Ricin , Monolith , Adsorption , Decontamination
