Title of article
Towards multivalent CD1d ligands: synthesis and biological activity of homodimeric α-galactosyl ceramide analogues Original Research Article
Author/Authors
Peter J. Jervis، نويسنده , , Marie Moulis، نويسنده , , John-Paul Jukes، نويسنده , , Hemza Ghadbane، نويسنده , , Liam R. Cox، نويسنده , , Vincenzo Cerundolo، نويسنده , , Gurdyal S. Besra، نويسنده ,
Issue Information
دوهفته نامه با شماره پیاپی سال 2012
Pages
11
From page
152
To page
162
Abstract
A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.
Keywords
dimer , ?-GalCer , Multivalency , CD1d , Click chemistry , iNKT cells
Journal title
Carbohydrate Research
Serial Year
2012
Journal title
Carbohydrate Research
Record number
967600
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