Author/Authors :
Peter J. Jervis، نويسنده , , Marie Moulis، نويسنده , , John-Paul Jukes، نويسنده , , Hemza Ghadbane، نويسنده , , Liam R. Cox، نويسنده , , Vincenzo Cerundolo، نويسنده , , Gurdyal S. Besra، نويسنده ,
Abstract :
A library of dimeric CD1d ligands, containing two α-galactosyl ceramide (α-GalCer) units linked by spacers of varying lengths has been synthesised. The key dimerisation reactions were carried out via copper-catalysed click reactions between a 6″-azido-6″-deoxy-α-galactosyl ceramide derivative and various diynes. Each α-GalCer dimer was tested for its ability to stimulate iNKT cells.
Keywords :
dimer , ?-GalCer , Multivalency , CD1d , Click chemistry , iNKT cells
