Title of article :
The metabolic and biochemical impact of glucose 6-sulfonate (sulfoquinovose), a dietary sugar, on carbohydrate metabolism Original Research Article
Author/Authors :
Juliana L. Sacoman، نويسنده , , Lauren N. Badish، نويسنده , , Thomas D. Sharkey، نويسنده , , Rawle I. Hollingsworth، نويسنده ,
Issue Information :
دوهفته نامه با شماره پیاپی سال 2012
Pages :
9
From page :
21
To page :
29
Abstract :
Increased activity of the main carbohydrate pathways (glycolysis, pentose phosphate, and hexosamine biosynthetic pathways) is one of the hallmarks of metabolic diseases such as cancer. Sulfoquinovosyl diacylglycerol is a sulfoglycolipid found in the human diet that possesses anticancer activity that is absent when its carbohydrate moiety (glucose 6-sulfonate or sulfoquinovose) is removed. This work used bacterial systems to further understand the metabolism of this sugar through three main carbohydrate processing pathways and how this could influence its biological activity. Using 13C NMR spectroscopy and enzyme assays, we showed that glucose 6-sulfonate cannot enter the pentose phosphate pathway, hence decreasing pentose and nucleotide biosyntheses. In glycolysis, glucose 6-sulfonate only provides one pyruvate per monosaccharide molecule, decreasing the flux of this pathway by half when compared to glucose 6-phosphate. Glucose 6-sulfonate can enter the hexosamine biosynthetic pathway by producing glucosamine 6-sulfonate, which is a reported antibacterial agent that competitively inhibits hexosamine production. All these interactions with carbohydrate routes might help explain the observed anticancer activity that glucose 6-sulfonate has in vitro. This adds to our knowledge of how vegetables rich in glucose 6-sulfonate can also act as metabolic inhibitors of pathways that are increased in metabolic diseases.
Keywords :
Glucosamine 6-sulfonate , Glucose 6-sulfonate , Pentose phosphate pathway , Sulfoquinovose , Metabolism
Journal title :
Carbohydrate Research
Serial Year :
2012
Journal title :
Carbohydrate Research
Record number :
967755
Link To Document :
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