Biodegradation of the iodinated X-ray contrast media diatrizoate and iopromide

The degradation of the iodinated contrast media diatrizoate and iopromide was investigated in laboratory tests. With regard to the expected behaviour of the contrast media in the environment, test systems with activated sludge, river water and river water plus sediment were established. In some of the experiments 14C-labelled contrast media were used to study degradation at low concentrations and to detect the transformation products. Degradation by as well as binding to aerobic-activated sludge of diatrizoate was poor, suggesting that this substance is hardly retained in sewage treatment plants. In systems with river water and sediment deacetylation of diatrizoate started after a lag period of 3 weeks and followed first order kinetics with rate constants of approximately 0.15 day−1. Two metabolites were formed that were stable until day 200 of aerobic incubation. Finally, further transformation of the aerobic metabolites was observed under anoxic conditions. In activated sludge, approximately 85% of iopromide were transformed into two metabolites. Like the parent compound they were highly hydrophilic and less than 16% were bound to sludge solids. In water/sediment systems, disappearance of iopromide started spontaneously with a first order constant of 0.04 day−1. One metabolite that was stable throughout the incubation period was formed with a delay of 20 days. In river water the concentration-dependent disappearance of iopromide was studied. The shortest half-life was 3.1 days at a concentration of 16.0 μmol l−1 and increased at concentrations below and above this value. The metabolites of iopromide were not identified, but partial deiodination of iopromide was shown. Mineralisation of the two contrast media or their metabolites to carbon dioxide was not observed.