Author/Authors :
Falahatkar، Siavash نويسنده , , Donyamali ، Hadiseh نويسنده Urology Research Center, Guilan University of Medical Sciences, Rasht , , Joafshani ، Mohammad Ali نويسنده Urology Research Center, Guilan University of Medical Sciences, Rasht , , Shahrokhi Damavand ، Reza نويسنده Urology Research Center, Guilan University of Medical Sciences, Rasht , , Hoda، Saba نويسنده , , Esmaeili ، Samaneh نويسنده Urology Research Center, Guilan University of Medical Sciences, Rasht , , Gholamjani Moghaddam، Keivan نويسنده Urology Research Center, Guilan University of Medical Sciences, Rasht , , Nikpour، Sara نويسنده ,
Abstract :
Purpose: To determine the frequency of human leukocyte antigen (HLA)-B5 in patients with
bladder cancer compared with normal population.
Materials and Methods: In this cross sectional study, from November 2009 until November
2010, 35 patients with pathologic diagnosis of bladder cancer who referred to urology clinic
of Razi Hospital were studied. Also, 130 healthy transplant donation volunteers who referred
for HLA-typing to Guilan Blood Transfusion Organization, were selected. Inclusion criterion
was pathologic diagnosis of bladder cancer regardless of stage and grade of tumor. Exclusion
criteria were presence of other urologic diseases. The information of these cases was extracted
from medical records, collected and analyzed.
Results: HLA-B5 was positive in 34.3% of the patient group and in 39.2% of the controls.
Statistical analysis showed no significant association between HLA-B5 and bladder cancer (P
= .15). There were no significant differences between grade (P = .107) and relapse (P = .327)
of bladder tumor with presence of HLA-B5.
Conclusion: There was no significant association between HLA-B5 and bladder cancer. The
grade and the relapse of tumor had no association with presence or absence of HLA-B5.
