Pharmaceuticals, personal care products and endocrine-disrupting chemicals in U.S. surface and finished drinking waters: A proposed ranking system Original Research Article

This study developed a comprehensive ranking system, for the first time as per authorsʹ knowledge, for prioritizing the monitoring of pharmaceuticals and personal care products and endocrine-disrupting chemicals (together termed as EOCs, hereafter; a total of 100 EOCs considered) in U.S. stream water/source water and finished drinking water (termed as “EOCRank,” hereafter). The EOCRank system was developed using a total of 4 criteria: (1) occurrence, (2) treatment in drinking water treatment plants, (3) ecological effects, and (4) health effects and characterized using 7 attributes: prevalence, frequency of detection, removal, bioaccumulation, ecotoxicity (for fish, daphnid, and algae aquatic indicator species), pregnancy effects, and health effects. The health effects attribute was characterized using 7 sub-attributes: carcinogenicity, mutagenicity, impairment of fertility, central nervous system acting, endocrine effects, immunotoxicity, and developmental effects. Rank scores of EOCs were calculated as summations of multiplications of importance weights and utility functions of multiple criteria and were arranged to highlight EOCs needing immediate attention. Two different ranking lists of EOCs were developed for U.S. finished drinking water and stream water/source water and observed to differ with each other, indicating the effect of water type on ranking of EOCs. A ranking list of priority EOCs, developed using a particular criterion, was observed to differ with that, developed using multiple criteria. Health effects and treatment criteria were observed to be important criteria influencing overall data gap rank scores and need further data collection. The generalized nature of the system could be customized for specific geographical locations (occurrence information and importance weights of different components). The developed database of the EOCRank system is available on: ).