Abstract :
Imaging time-of-flight secondary ion mass spectrometry (TOF-SIMS) was used to study the localization of heterocyclic
amines in MCF-7 line of human breast cancer cells. The detection sensitivities of a model rodent mutagen, 2-amino-1-methyl-6-
phenylimidazo[4,5-b]pyridine (PhIP), were determined. Following an established criteria for the determination of status of
freeze-fracture cells, the distribution of PhIP in the MCF-7 cells was reported.
# 2004 Published by Elsevier B.V.
