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MICRODOSE 14C UREA BREATH TEST FOR THE DIAGNOSIS OF HELICOBACTER PYLORI: A SURVEY IN IRANIAN POPULATION.

DOWLATABADI BAZAZ Reza نويسنده , KHALAJ Ali نويسنده , BEIKI Davood نويسنده , EFTEKHARI Mohammad نويسنده , AL-SEYED HOSEIN Mohammad Hosein نويسنده , KHOSHAYAND Mohammad Reza نويسنده

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The carbon -14 urea breath test (UBT)is a non-invasive and simple method for the diagnosis of Helicobacter pylori infection. Attempts have been made to use lower doses of l4C-urea in the UBT in order to reduce the radiation risk of the test. The aim of this study was to assess the accuracy of a microdose (1 jiiCi [37 KBq]) 14C-UBT in Iranian population for validation of its diagnostic accuracy against gold standard methods. Eighty and two patients were subjected to upper gastrointestinal endoscopy as well as 14C-UBT in one week. Rapid urease test and histological examinations were used as gold standard. Breath samples were collected 10, 20 and 30 minute after ingestion of 1 /xCi of I4C- urea solution and their activities were measured using a scintillation counter and expressed as counts per minute (cpm) and disintegration per minute (dpm). Good agreement was observed between the I4C-UBT and gold standard for samples which were collected 20 minutes after 14C-urea administration. The I4C-UBT showed 100% sensitivity, 95% specificity, 95.45% positive predictive value, 100% negative predictive value and 97.50% accuracy. The results of this study showed good concordance between the 14C-UBT and invasive methods.

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