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Synthesis and Characterization of Polymethacrylamide Having Gabapentin Moieties

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The synthesis and radical polymerization of methacrylamide having Gabapentin (GBP) moieties were examined. The monomer was prepared by reaction of methyl-1-aminomethyl-1-cyclohexane acetic acid salt with methacryloyl chloride in presence of triethylamine in moderate yields. Radical polymerizations of the monomer were carried out in presence of AIBN (3 mol%) in DMF in moderate yield. The thermal behaviour of the polymers was investigated by thermogravimetric analysis (TGA) and differential scanning calorimeter (DSC) to determine the thermal degradation pattern and glass transition temperature (Tg)י The resulting polymer showed a thermal stability up to - 400°C. We found the molecular weight of the polymer to be 4340 g/mol (Mw/Mn=1.33) and poly[N-[(1-1-methoxyformoyl-1 י-methyl) cyclohexylmethyl] methacrylamide] (poly[MFCHM]) were soluble in common solvents.

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