چكيده لاتين :
Meloxicam is a poorly water soluble non steroidal anti-inflammatory drug and antipyretic
agent. The aim of the present work was to investigate the effect of different types of carr iers
on in vitro dissolution of meloxicam. Meloxicam solid dispersions were prepared by physical
mixing, co-grinding and solvent evaporation methods with polyethylene glycol (PEG) 6000.
The effect of solubilization by sodium lauryl sulphate (SLS) was also studied. The dissolution
was determined by USP XXVII Apparatus I, using phosphate buffer with a pH of 7.4 as the
dissolution medium. The maximum in vitro dissolution of meloxi cam, i.e. 97.45% in 60 min,
was observed for solid dispersions containing meloxicam (150 mg), PEG 6000 (350 mg) and
SLS (75 mg) prepared by solvent evaporation method containing a sum of 3 g of Lactose and
MCC (4: 1) as additives. The general trend indicated that there was an increase in dissolution
rate for solid dispersions containing the solubilizer SLS. The best-fit model indicating the
mechanism of dissolution from the formul ation showing the highest release for was found
to be Higuchi matrix release (r=0.9774 , b=13.042, a=2.4798). Infra red spectroscopy (IR)
indicated that meloxicam in solid disper sions showed physi cal entrapment. The increased in
dissolution rate of meloxicam by solid dispersion technique may be due to increase wettability
and hydrophilic nature of carrier.
