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Synthesis and Antimicrobial Activity of Some New Isatin Derivatives

Patel Ankur نويسنده , Bari Sanjay نويسنده , Talele Gokul نويسنده , Patel Jitendra نويسنده , Sarangapani Manda نويسنده

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Some new 3-[(5-benzylidene-2-phenyl)-3, 5-dihydro-4-H-imidazol-4-one-3-(4bezoylhydrazono)]- indole-2-ones (VIII) have been synthesized from different isatinhydrazones (II) by condensing with 2-phenyl-5-benzylidene- 3-N (4-acetyl phenyl)-l, 5-dihydro-imidazol4- one (VII). Their chemical structures have been confirmed by IR, IHNMR, MASS and by elemental analysis. Investigation of antimicrobial activity of compounds was done by the disk diffusion technique. Among the compounds tested, the compound with 5-Br substitution showed the most favourable antimicrobial activity.

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