17062

Effect of Vitamins A, E, C and Omega-3 Fatty Acids on Lipid Peroxidation in Streptozotocin Induced Diabetic Rats.

Javadi E. نويسنده , Sadeghi M.R. نويسنده , Mostafavi E. نويسنده , Fatehi F. نويسنده , Fakher SH. نويسنده , Djalali M. نويسنده , Tabei SMB. نويسنده , Zeraati H. نويسنده

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Background: To assess the effect of supplementation with vitamins A, E and C and (omega)-3 fatty acids on lipid peroxidation in streptozotocin (STZ) induced diabetic rats. Methods: Sixty four male wistar rats weighting 250g were divided into four groups as normal control, diabetic control, diabetic with vitamin A, E as well as C supplementation and diabetic with (omega)-3 fatty acids supplementation. After four weeks of treatment the rats were anesthetized and malondialdehyde (MDA) levels were investigated in blood samples, liver and heart homogenate.Results: In diabetic rats MDA level in plasma, liver and heart was significantly more elevated than normal control rats (P<0.05). Vitamin A, E and C supplementation caused significant decrease in plasma, liver and heart MDA (P< 0.05). A significant decrease in heart MDA (P< 0.05) was observed in diabetic rats with (omega)-3 fatty acids supplementation. Conclusion: Supplementation of vitamin A, E and C and (omega)-3 fatty acids was found to decrease lipid peroxidation to some extent in diabetic rats and they can be valuable candidates in the treatment of the complications of diabetes .

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