مرکز منطقه ای اطلاع رساني علوم و فناوري -

چكيده لاتين :

Angiotensin l-converting Enzyme (A E) gene polymorphism; genotype DD or D allele may be involved with an increased susceptib ility to type 2 diabetes and diabetic nephropathy (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in Tehran , Iran. DNA was extracted from the white blood cells and the liD polymorphism of the ACE gene was detected by PCR. The frequency of DO. ID and II genotypes in type 2 diabetic patients were 20%, 61.2% and 18.8%, and in patie nts with nephropathy 30.6%, 55.3%,1 4. 1%, respectively . The DO genotype of the D group was higher than that of the type 2 diabetes patients (30.6% vs 20%, P=0 .157. RR=1.3) and the control group (30.6% vs 14.3%, P=0.006, RR=2.9). The frequency of D allele in nephropat hic patients was 58.2% as compared to the type 2 diab tic patients without nephropathy (50.5%) P=O.19 RR=1.l6. The D allele frequency in the DN group was found slightly higher than of the type 2 diabetes (X2=0.684, OR=O.709, 95%CI: 0.313-1.606, ?=DA08) which indicated the D allele was not associated with DN. It is suggested that DD genotype and 0 allele are not associated with diabetic nephropathy.