پديد آورندگان :
Habibey Rouhollah نويسنده , Ajami Marjan نويسنده , Hesami Ali نويسنده , Pazoki-Toroudi Hamidreza نويسنده
چكيده لاتين :
Renal ischemia reperfusion (IR) injury has been a major source of concern during the past
decades and angiotensin converting enzyme (ACE) inhibitors have been successfully used to prevent this
injury. There have been some controversial reports about the involvement of KATP channels in the mechanism
of action of ACE inhibitors. In this study, we examined the effect of KATP channel blocker (Glibenclamide) on
preventive effect of captopril on renal IR injury. Methods: Male sprauge-dawley rats were pretreated with
glibenclamide (1, 5 and 25 mg/kg) and/or captopril (5 mg/kg). They were anesthetized using ketamine (50
mg/kg) and xylazine (10 mg/kg). The left flank was incised and the left renal artery was clamped for 30
minutes. After that, the kidney was reperfused for 2 hours and then the animal was killed. The Right and left
kidneys were removed and evaluated for microscopic damage. Results: Captopril reduced renal IR injury
while glibenclamide by itself caused no change. Glibenclamide did not change the preventive effect of
captopril. Conclusion: It seems that the preventive effect of captopril is not directly mediated by KATP
channels and further attention should be paid to other receptor-mediated angiotensin II effects. Iran. Biomed. 1.
12 (4): 241-245, 2008
