18219

Synthesis and Study of Antitumor Activity of Substituted Imidazolecarboxamides

Hadizadeh Farzin نويسنده , Ramezani Mohammad نويسنده , Tayarani Zahra نويسنده , Eghbal Maryam نويسنده

239

244

6

In view of potential biological activities of small molecule poly amides, we synthesized some novel N-(2-aminoethyl)-1-benzyl-2- (alkylthio)-lH-imidazole-5carboxamide (7a,b), and N-(2-(l-benzyl-2-(alkylthio) -Hl-imidazole- 5-carboxamido) ethyl)-1-benzyl-2- (alkylthio)-lH-imidazole-5-carboxamides (8a,b) as antitumor agents. The antitumor activity of compounds 7a,b and 8a,b was studied at concentrations of 0.01,0.1 and 1 mg/ml, using the potato disk bioassay technique. Vincristine at 0.25 mg/ml employed as positive control and had -67.24% tumor inhibition. Maximum % inhibition for potato tumors was found to be -75.52 for 7b at 1 mg/ml.

1202187