چكيده لاتين :
Antiphospholipid antibodies (APLA) may be detected in normal
pregnancies and also may cause thrombosis, recurrent
fetal loss, placental infarction and preeclampsia. In the present
study the possible differences in APLA titer between healthy
pregnant women and preeclampsia cases without history of
thrombosis was examined. The APLA titer in 50 healthy pregnant
women with 50 preeclampsia cases without the history of
thrombosis and autoimmune disease was compared. Preeclampcia
is defined as hypertension ~ 140/90 mmHg after 20
weeks of gestation and proteinuria(GREATER THAN) 300mg/24h. IgG and IgM
anticardiolipin antibodies were measured by immunoassay
methods and Teclot kits for lupus-l ike anticoagulant antibodies
were used. In normal pregnant women, 6% had lupus-like
anticoagulant antibody, 12% had IgG anticardiolipin antibody,
and 26% had IgM anticardiolipid antibodies. In preeclapsia,
8% lupus-like anticoagulant antibody, 4% had IgG anticardiolipin
antibody, and 30% had IgM anticardiolipid antibodies.
Despite the evidence of prothrombotic state during preeclampsia,
it is unlikely that anti phospholipid antibodies represent as
a risk factor for preeclampsia among women without the history
of thrombosis or autoimmune diseases.
