چكيده لاتين :
Background: Saliva is an alternative biological matrix in drug
testing. It has several advantages in comparison with other
biological fluids such as blood and urine. C:::Jlection of saliva
is simple, noninvasive and can be controlled under direct observation
in drug abusers, or opium addicts.
Methods: In the present study we report our experience with
saliva collection, liquid-liquid extraction and quali-quantitation
of morphine abuse. The GC-MS method was applied to the
analysis and determination of morphine in saliva samples obtained
from addicted persons.
Results: LOD of the method was lng/ml and LOQ 5 ng/ml,
with acceptable within-and between-day reproducibility and a
linearity (r^2=O.998) over a concentration range from 5 to
500ng/m\.
Conclusion: The results of this study indicated that saliva
may have potential use for identification of patients suspected
to drug abuse.
