چكيده لاتين :
The goal of this study was to evaluate the effects of quercetin and ACTH
injection on prevention of development of morphine tolerance and dependence in
mice. In this study different groups of mice received morphine (40 mg/kg, i.p.) plus
quercetin (5, 10, 25 mg/kg, ip), ACTH (1, 2.5, 5 IU/mice, i.p.), or combination of
quercetin (5 mg/kg) and ACTH (1 IU/mice) once a day for four days. Tolerance was
assessed by administration of morphine (9 mg/kg) and using hot plate test on the
fifth day. It was found that pretreatment with quercetin or ACTH decreased the degree
of tolerance. Co-administration of quercetin and ACTH before morphine did not
decrease the tolerance, significantly. From these results it may be concluded that
administration of quercetin or ACTH alone could prevent the development of
tolerance to the analgesic effects of morphine. These effects may be related to as
nitric oxide inhibitor (eNOI) behavior of quercetin and the ability of morphine and
their receptors in the control of the secretion of CRH.
