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Tetrabutylammonium Bromide Promoted Efficient and Chemoselective Trimethylsilylation of Primary and Secondary Alcohols Under Mild Reaction Conditions

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This article is dedicated to Professor Habib Firouzabadi on the occasion of his 65th birthday, for his great contribution to the development of organic chemistry in Iran. A mild and efficient method for trimethylsilylation of alcohols with hexamethyldisilazane (HMDS) catalyzed by tetrabutylammonium bromide is reported. The method is highly chemoselective for the o-protection of primary and secondary alcohols in the presence of amines, thiols and tertiary alcohols.

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