19827

Association between the Polymorphism of TGF-(BETA)1 Gene Promoter (-509C(GREATER THAN)T) and Idiopathic Chronic Urticaria

Hosseini Farahabadi Sara نويسنده , Tavakkol-Afshari JaLal نويسنده , Ganjali Rashin نويسنده , Rafatpanah Houshang نويسنده , Ghaffad Javad نويسنده , Farid-Hossein Reza نويسنده

109

113

5

Idiopathic Chronic Urticaria (ICU), the most common form (70-80%) of chronic urticaria is supposed to have immune basis causes. It is speculated that the promoter polymorphism ofTGF-(BETA)1 gene may be involved in ICU. This condition is thought to affect at least 0.[0;0 of the population and often can be severe and difficult to treat. A total of 40 patients with leU and 41 normal subjects were studied. DNA was extracted from whole blood and TGF-(BETA)1 promoter -509C(GREATER THAN)T polymorphism was determined by PCRRFLP method. Out of the 40 patients with ICU, 11 (27.5%) had CC, 2() (65%) had CT and 3 (7.5%)) had TT genotypes, A higher proportion of case subjects with the C allele (CT type or CC type) was found compared with the T allele. These results do suggest an influence of gcnetic variability at the promoter of TGF-(BETA)1 gene (-509C(GREATER THAN)T) on the occurrence of ICU. This polymorphism has been shown as a useful gcnetic change in our study. Furthcr work is required to confirm this result,

1203853