چكيده لاتين :
Background and the purpose ofthe study: Ichnocarpus frutescens has been widely used in the
traditional medicine for the treatment of a variety of diseases. In the present study antiinflammatory
and antioxidant property of roots of this plant was investigated.
Methods: The anti-inflammatory activity of methanolic extract of Ichnocarpus frutescens
(MEIF) was evaluated by carrageenan, and cotton pellet induced granuloma tests to
determine its effects on acute and chronic phase of inflammation models in rats.
Results and major conclusion: Preliminary Phytochemical analysis of methanolic extracts
showed presence ofterpenoids, flavonoids, and sterols. Maximum inhibition (54.63 %) was
obtained at the dose of 100 mg/kg after 3 hrs of drug treatment in carrageenan induced paw
oedema, whereas indomethacin produced 57.65 % of inhibition. In the chronic model, 300
mg/kg of MEIF like indomethacin and dexamethasone standard drug decreased formation
of granuloma tissue by 22.64, 29.63 % and 34.84 % respectively. The successive methanol
re-extract of Ichnocarpus frutescens root (MEIF) exhibited strong scavenging effects on 2,
2-diphenyl-2-picryl hydroxyl (DPPH) free radical, nitric oxide, super oxide anion, hydroxyl
radical and inhibition of lipid peroxidation. These results clearly indicate strong antiinflammatory
and antioxidant properties of Ichnocarpus frutescens root.
