چكيده لاتين :
Background: Halothane and isoflurane inhibit glucose-induced insulin secretion in animal
and in vitro experiments.A randomized trial was designed to determine their in vivo effects
in diabetic patients.
Methods: Sixty diabetic patients with various malignancies were randomized to receive
anesthesia with either halothane or isoflurane. Blood glucose level (BGL) was measured
before induction and every 30 minutes during surgery and then after operation in the
recovery room.
Results: Patients in both arms matched with gender, age, operation time, and initial BGL.
In both arms an increase in blood glucose level could be detected 30 minutes after
induction of anesthesia, but higher in the halothane arm. This difference was maintained
for the next 30 minutes as well as the rest of duration of the anesthesia. Both arms had
higher blood glucose levels after operation compared to initial, pre-anesthesia state, and
this increase was more conspicuous in the halothane arm. No Halothane toxicity was
detected during hospitalization.
Conclusion: Although the effects of stress hormones was not evaluated, halothane
anesthesia caused a greater degree of hyperglycemia compared to isoflurane anesthesia.
This might be secondary to halothaneיs greater inhibitory effect.
