20759

Characterization and Antimicrobial Activity of Organotin(IV) Complexes of 2- [(2י ,6י-diethylphenylamido)]benzoates and 3-[(2י ,6י-diethylphenylamido)]propanoates

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New organotin (IV ) complexes with 2- [(2י,6י-diethylphenylamido)] benzoic acid (HL1) and 3- [(2י,6י diethylphenyl amido)]propanoic acid (HL2) were synthesized by the reaction of di- and triorganotin salts in the presence of triethylamine as base ordioctyltin oxide using a Dean and Stark trap for the removal of azeotropic water. All complexes were characterized by elemental analysis, IR , NMR , and mass spectral studies , and proof that tin-ligand coordination involves only the carboxylate group and complexes show hexa-coordinated geometry in solid state. Multinuclear NMR data show that triorganot in complexes exhibit 4-coorclinated geometry while diorganotin complexes show a coordination number greater than 4, probably 5 or 6 in solution state. These complexes were screened to check their antimicrobial activity in vitro. The complexes of 2-[(2י,6י-diethylp henylamido)]benzoic acid (HL1) were also checked for their insecticidal and anti-Ieishmanial activity. All the complexes show significant activity with few exceptions.

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