چكيده لاتين :
Phage-displayed random peptide libraries (RPL) provide a powerful technique for
identification, structural and functional analysis of ligands for many different target
molecules, including, antibodies, receptors or other proteins. This strategy has been verified
to be an effective tool for research in immunology and successfully has been used to
determine the target sequence for monoclonal and polyclonal antibodies. The peptide library
approach provides great promise for characterization of ligands with no prior information
concerning antibody specificity. This would allow the recognition of candidate antigens
involved in initiation or perpetuation of autoimmune diseases. This technology also offers
the potential for new therapeutic opportunities, production of diagnostic reagents, or even
development of effective new vaccines. This review focuses on studies regarding the
identification of autoantigens recognized by antibodies in autoimmune diseases using phagedisplay
peptide libraries.
