Effect of bee venom on rat glucocorticoid receptor beta: a therapeutically model of rheumatoid arthritis

This study aim to use bee venom as alternative medicine for treatment of rats induced with rheumatoid arthritis. Forty ratsused for this purpose which divided into four groups, three groups induced with rheumatoid arthritis and one group consideredas control group that subdivided into control negative and control positive (rheumatoid group). All the groups induced withrheumatoid arthritis injected with bee venom with different doses (high 40 μg/kg and low dose 10 μg/kg) and different times(after 5 days and after two weeks from CFA injection and along with CFA injection). Glucocorticoid receptor beta used as abiomarker which suggested function as negative regulator determine glucocorticoid sensitivity in target tissues and as anendogenous inhibitor for glucocorticoid action. The high and low dose showed significantly decrease in GCRβ as comparedwith control group and non-significant between rheumatoid and both along CFA and after 5 days of CFA injection. The pretreatmenthigh and low dose revealed significant decrease in GCRβ compared with Rheumatoid group and non- significant ascompared with control group in low dose bee venom treatment. Also, depending on hand paw edema assessment, a weakevidence about anti-inflammatory effects of bee venom has shown. From our data we concluded that bee venom preventsGCRβ elevation especially in pre-treatment group this may result assess to anti-inflammatory effect but the safety of this toxinstill needed for another study. Clinically no evidence about the treated effect of bee venom on rheumatoid arthritis in rat.