التاثيرات المرضية للستيرويد البنائي سستانون في خصى الجرذان

This study was designed to investigate the pathological effects of the anabolic androgenic steroid stanon at different concentrations on the testes of male rats. The experiment included 100 rats divided randomly into 5 groups of 20 rats for each group, where the first group was a negative control group that was given the usual water and feed, the second group was a positive control group that was injected with sesame oil weekly for 60 days and by intramuscular injection. The third, fourth and fifth groups were treated with diluted stasanone compound in concentrations (5, 10 and 20) mg/kg of body weight, respectively weekly for 60 days and by intramuscular injection. Then the animals were dissected and testis models were taken at periods 15 and 30 and 60 days after treatment and placed in Bones' solution, then transferred to buffer buffer equivalent 10% formalin, then 5 rats from each group were left after the last treatment, where they were given water and feed only for 30 days to observe whether the gross and histological changes are progressive or reversible. All groups treated with Stanon showed gross and histological pathological changes in the testicles, represented by macroscopic atrophy and histological testicular degeneration, with irregular arrangement of seminiferous tubules, as well as degenerative sperms with infiltration of inflammatory cells, edema, and disappearance of testicular tissue features, especially at the 60-day period of treatment. Changes even after leaving animals for 30 days on feed and water only after the last dose and for all doses used. We conclude from this study that stastanon at doses of 5, 10 and 20 mg/kg of body weight and during periods of 15, 30 and 60 days had a direct effect. On the testis of male rats and these changes persisted even after stopping treatment for 30 days and these changes were progressive.