Evaluation of Oxidative Stress with Thyroid Function in Growth Hormone-deficient Children from Misan Government ,Iraq

Aim: Growth hormone deficiency (GHD) is a complex endocrine syndrome, which is most commonly known to affect the pediatric population. However, adults also suffer from GHD, and it is often seen as part and parcel of the aging phenomenon. We aimed to investigate the levels and relationships of antioxidants, lipid peroxidation and thyroid function with altogether in growth hormone deficiency Method:This study was conducted to measure a group of hormones related with infected individuals with the shortage of the growth hormone by studying 57 sample Which represents patient groups were ( 38 boys and 19 girls ) divided in to two groups according to age Group (1): consist of 26 patients (boys 14 and 12 girls ) their aged ranged from 2 to 8 years and Group (2) Consisted of 31 patients ( 24 boys and 7 girls ). Their ages ranged from 9 to 16 years in comparison with 50 samples taken from normal individuals as a control group. The concentration of hormones has been measured were human Growth hormone (hGH) Total Triidothyronin(TT3), Total Thyroxin (TT4),Free Thyroxin (FT4)Thyroid Stimulating (TSH), serum malondialdehyde (MDA) ,Vitamin C , Erythrocyte superoxide dismutase (SOD) activity, plasma Total antioxidant capacity (TAC) Results: the children for growth hormone has been found decrease significantly in thyroid hormone as ( T3. T4 ) while non significantly in (FT4) , and highly increased significantly in (TSH) level in patient compared with control group To evaluate the blood oxidative as (MDA) and antioxidant status the MDA and TAC levels were significantly lower in patients group than in the control group, . in addition , the SOD was non-significant, as for the vitamin C showed a significant highly change in the patients group compared with control group and this result was remarkable for the increase, where the results (5.61± 0.73 vs 3.89± 0.72) mg/dL.Conclusions: This work has demonstrated that some parameters of the blood oxidative and antioxidant system are out of balance and relationship with thyroid function as thyroid hormone even impaired in GHD children should be taken into account.