SECONDARY AMYLOIDOSIS ASSOCITED WITH Salmonella typhi EXPERIMENTAL INFECTION IN WHITE MICE

The present paper reported induction of amyloidosis by intraperitoneal injection of Salmonella typhi in white mice. The study was on young mice of 5–6 weeks old, after two weeks acclimatization period, mice were injected intrapritoneally with 0.25 ml of S. typhi suspension containing 2.5 x 108 bacterial cells and sacrificed daily for 28 days. The amyloid was systemic, secondary in character and organs mostly affected were spleen, kidney and liver, respectively. It appeared that this is the first report remarks the induction of systemic secondary amyloidosis by intra peritoneal injection of Salmonella typhi in young white mice.