دراسة القدرة التثبيطية للمستخلص المائي الخام لاوراق نبات لا لا عباس Mirabilis jalapa على نمو خلايا الخط السرطاني RD والخط السرطاني AMN-3

STUDY THE INHIBITION ACTIVITY OF THE CRUDE HYDRO EXTRACT OF MIRABILIS JALAPA ON CELL LINE RD an‎d AMN-3

AbstractThis study was conducted to figure on the inhibitory ability of the Aqueous Four O'clock plant(F.O.P), Mirabilis jalapa leaf extract on the RD and AMN-3 cancer lines.A crude aqueous F. O. P. leaf extract has been prepaired with four concentrations, 125, 250, 500 and 1000 Mg/ml to be exposed on the RD and AMN-3 cancer lines with exposure periods 24 , 48 and 72 hrs. This study has revealed the existence of an inhibitory effect of the extract (P<0.001) on killing the cells of both cancer lines for all concentrations as compared to control.The inhibitory effect has increased as concentration has increased. The killed cancer cells have increased significantly as concentration and time of exposure have increased as compared to control. The optimum exposure time was after 72 hrs in both cancer lines. There was an inversal linear relation ship between concentration and cell growth after the exposure periods 24 and 48 hrs; whereas, a non-linear relation ship was found between concentrans and cell growth after 72 hrs.