Synthesis and characterization of new 2-Substituted Tetracycline derivative using -D-fructopyranose

derivative of tetracycline at position 2 has been synthesized via way involved treatment of 1-chloro diacetone fructose with tetracycline to give derivative (IV), then the protected groupswere removed using diluted acid. The Structures of the prepared compounds were elucidated onthe basis of UV, FTIR and 1H-NMR spectral data which agreed with the proposed structures.The solubility studies proved that the new derivative of tetracycline be more soluble in polarsolvent compared than free drug.