Leuconostoc mesenteroides cause Nosocomial UTI At a tertiary care center in North India

Eight strains of gram-positive cocci highly resistant to vancomycin (MICs of 512 - 1,024 μg/mI) were isolated from urine sample. These organisms were identified as Leuconostoc mesenteroides. They were tested to determine susceptibility to 12 antimicrobial agents by agar dilution method. Out of 8 isolates of L. mesenteroides, all of these isolates (100%) were resistant to vancomycin and 6 (75%) were resistant to teicoplanin. Seven (87.5%) isolates were sensitive to clindamycin, 6 (75.0%) isolates were sensitive to chloramphenicol, erythromycin, gentamicin and streptomycin, 5 (62.5%) isolates were sensitive to ampicillin, penicillin G and tetracycline, while 4 (50%) isolates were sensitive to kanamycin and Trimethoprim. We are reporting nosocomial UTI caused by these organisms. The results provide evidence for the possibility of nosocomial transmission of this unusual opportunistic, vancomycin-resistant pathogen.