استجابة فقر الدم عند مرضي التحال الدموي المزمن في مشفي الاسد الجامعي في اللاذقية للعلاج بالاريتروبوئيتين

This study was carried out in the Hemodialysis Unit at AL-Assad University Hospital, Lattakia, and included 67 patients with chronic hemodialysis for more than 6 months, treated by erythropoietin and oral iron compounds for 4 months at least. We found out low responsiveness to treatment (Hb < 10g/dl) in 49 patients (73.13%). The major cause of low responsiveness was absolute iron deficiency (low body iron stores) expressed by low serum ferritin. Other causes were chronic inflammatory states and severe hyperparathyroidism . We conclude that: - We have to correct body iron stores before initiating therapy with erythropoietin and make regular assessment of iron state during therapy. - The oral administration of iron is inadequate and the IV route is preferable in these patients. - We have to find out and treat chronic inflammatory states and hyperparathyroidism.