دور البروجسترون في الوقاية من الولادة الباكرة

The objective of this study is to evaluate the effectiveness of prophylactic use of 17- OHPC in preventing recurrent preterm delivery in women with a documented history of a previous spontaneous preterm birth. This study includes 80 pregnant women divided into two groups: The first includes 50 pregnant women receiving weekly 17- OHPC injections (250mg) from( 16-20) weeks up to 36weeks or delivery. The second group included 30 pregnant women receiving progesterone. We find that the recurrence of preterm birth is significantly less for women treated with17- OHPC (28%) compared to those (43.3%)who have not been treated. Women in the second group are significantly more likely to have spontaneous recurrent preterm birth at( <37,<35,<32) weeks of gestation (43.3%,23.3%,13.3%) compared to women who receive progesterone ( 28%,14%, 28%).