ارتباط ميزان فعاليت بدني با غلظت لپتين و ليپوپروتئين هاي سرم خون بانوان چاق

برنامه های پیشگیری، كنترل و درمان چاقی براساس دو اصل كاهش انرژی دریافتی و افزایش انرژی مصرفی طراحی و اجرامی شود. لپتین به عنوان یك عامل ناظم میزان انرژی دریافتی و فعالیت بدنی به عنوان یك عامل افزاینده انرژی مصرفی نقش مهمی دركنترل و درمان چاقی دارند. فهم این نكته كه تعامل و ارتباط این دو عامل بر یكدیگر و بر فرایند كنترل چاقی چگونه است، می توانددریچهای نو در پیشگیری، كنترل و درمان چاقی باشد. پژوهش حاضر در نظر دارد تا ارتباط هم بستگی حداكثر اكسیژن مصرفی بهعنوان شاخص میزان فعالیت بدنی را با سطح لپتین و لیپوپروتئین های سرم خون بانوان تعیین و توصیف نماید تا مشخص شود كهدامنه این ارتباط چگونه است؟ آیا افزایش میزان فعالیت بدنی و تمرینات ورزشی مناسب و مداوم نمایانگر دریچه ای نو در پیشگیری،كنترل و درمان چاقی است؟

Decrease of energy intake and increase of energy uptake that can be leaded to negative energy balance, are two principles of obesity prevention, control and treatment programs. Leptin hormone, as a regulator of energy intake level and exercise training, as an increaser factor for energy expenditure level; play an important role to prevention, control and treatment of obesity. Understanding of correlation, interaction and effect of these factors together and on obesity process, can be new view in prevention and control of obesity. Methodology: The aim of this cross-sectional study was to determine and compare of correlation between Physical Activity Rating and concentration of serum Leptin and Lipoproteins in randomly selected of over weight females (20-50 yrs). This analytical study was performed in 72 subjects who were voluntarily participated, was based on National Health Interview Survey and Physical Activity Rating questionnaire; [Age: 33.00 ± 9.90 yrs, BMI: 24.49 ± 3.01 kg/m2, %fat: 29.07 ± 5.58]. Estimated VO2max (30.27 ± 7.03 ml.kg-1.min-1) as an physical activity rating index estimated was based on non-exercise prediction equations for VO2max was developed by researchers at the university of Houston; using Age, Gender, Physical Activity status and Body Fat percent. Fasting serum concentration of Leptin (33.93 ± 13.50 ng/ml); TC (175.12 ± 33.61 mg/dl); LDL–c (110.30 ± 26.40 mg/dl); HDL–c (46.07 ± 12.15 mg/dl) were measured. Serum Leptin was measured by ELISA method; and Serum TC, LDL-c and HDL-c was measured by enzymatic method; with ROSHE full automated auto analyzer, using pars azmoon kits. The Normality of variable distribution tested with, kolmogorov-Smirnov test. Significantly of Pearson and Spearman correlation coefficient and compare of this coefficient tested with T-Fisher and Z-Fisher tests, respectively (p≤0.05). Results: Correlation coefficient between estimated VO2max and Leptin (r = -0.511** , P ≤ 0.001), LDL-c (r = -0.432** , P ≤ 0.001), HDL-c (r = 0.256* , P = 0.030), TC (r = -0.262* , P = 0.026), BMI (r = -0.617** , P ≤ 0.001) and Fat percent (r = -0.847** , P ≤ 0.001) were significant. Discussion and Conclusion: Results demonstrated that a reverse and significant association between estimated VO2max with serum concentration of Leptin and Lipoproteins that might be due to effects and strongly reverse relation between physical activity rating with females body fat percent.