Neurocognitive impairment, Mental health status clinical and biochemical toxicity biomarkers in farmers exposed to organophosphate pesticides

The aim of this study was to study toxicity of organophosphate (OP) pesticides in exposed farmers in terms of neurocognitive impairment, Mental health status, clinical symptom, diabetes and hematological factor. A comparative cross-sectional analysis was done in 174 farmers who have been exposed OPs in comparison to a control group containing 174 healthy subjects with the same age and sex and education level. The levels of Fasting blood glucose, Blood urea nitrogen(BUN), cholesterol, triglycerides, Creatinine, High-density lipoprotein (HDL), Aspartate aminotransferase (AST) and Alanine aminotransferase (ALT) and alkaline phosphates (ALKp) were measured in the blood of subjects. The mean level of Fasting blood glucose, BUN, cholesterol and ALT was significantly raised in workers while Creatinine, triglycerides and Alkalin phosphatase significantly decreased as compared with controls. The mean levels of AST and Fbs2 in the workers and controls were not statistically different. The neurocognitive impairment and psychological disorders were significantly raised in workers..Clinical examination was done in order to record any abnormal sign or symptoms. Farmers showed clinical symptoms such as eczema, saliva secretion, fatigue, headache, sweating, abdominal pian, ,nausea , disfoghani, distahtani, protahtani, azolate shekami, hand tingling, foot tingling, epiphoria, edrar, myosis, dyispnea, bradycardia, nasal flowing. The present findings indicate that inhibition of AChE can be incidence of neuropsychological disorders and pre diabetes. Use of supplementary antioxidants would be useful in the treatment of farmers