Simple solution to prevent prostate cancer

Based on the researches , one of the most common cancer among the men is malignant prostate cancer. Which seen after surgery and gland removing completely the amount of PSA in patient increases again and available drugs which have severe side effects cannot affect on rising the PSA. One parameter that without it cancer cells are not able to reproduce is Glutamine Amino Acid. With studying humanity biochemical pathway and Glutamine Amino Acid reabsorbing pathways by cancer cells we understand that two material Ursolic Acid and Resveratrol could dock with a lots of Allosteric Enzymes inside the reabsorbing pathway Glutamine Amino Acid by cancer cells. That inactive enzymes therefore more than 90 % reabsorbing pathways Glutamine Amino Acid will be closed. Docking these two materials Ursolic Acid and Resveratrol with Allosteric enzymes reabsorbing pathways Glutamine Amino Acid by cancer cells and inactivating enzymes with softwares Autodock-vina and QSAR has been checked. Also Curcumin could activate Apoptosis in prostate cancer cells. High-throughput screening of a natural compound library was performed to identify the most efficacious combinatorial treatment on prostate cancer. Ursolic acid, curcumin and resveratrol were selected for further analyses and administered in vivo via the diet, either alone or in combination, in a mouse allograft model of prostate cancer. All possible combinations of these natural compounds produced synergistic effects on tumor size and weight, as predicted in the screens. A subsequent untargeted metabolomics and metabolic flux analysis using isotopically labeled glutamine indicated that the compound combinations modulated glutamine metabolism. In addition, ASCT2 levels and STAT3, mTORC1 and AMPK activity were modulated to a greater extent by the combinations compared to the individual compounds. Overall, this approach can be useful for identifying synergistic combinations of natural compounds for chemopreventive and therapeutic interventions.